Daily injections for type 1 diabetes could be replaced

Insulin injections could be replaced by tablets
on Thu 12 Jul

 

As I mentioned in my blog post last September the World Health Organisation revealed that diabetes has rapidly become a significant global health challenge with a four-fold increase in worldwide cases of diabetes over the last 25 years.

 

In this country alone figures released by Diabetes UK show almost 3.7 million people living with a diabetes diagnosis, estimating that approximately one in ten of these people have type 1 diabetes.

 

Of those with type 2 diabetes (usually controlled with lifestyle change and tablets initially) approximately 25% will eventually require treatment with either insulin alone or added to tablet or via injection therapies.

 

I should imagine that those 370,000 people who presently require insulin injections at least twice a day are going to be very interested in new research from America which appears to have identified a way to take a tablet rather than have to inject.

 

This development has been more difficult than you might imagine as the protein in insulin doesn’t react well in the acidic environment of the stomach and its absorption by the intestine is poor.  To overcome this insulin is carried in an ionic liquid and then put inside a capsule which has an acid resistant coating.

 

The senior author of this research – Samir Mitragotri – says “Our approach is like a Swiss Army knife, where one pill has tools for addressing each of the obstacles that are encountered

 

The researchers believe that orally ingested insulin has additional benefits in that it would more closely mimic the actions of a healthy pancreas; and could obviously alleviate both the adverse effect of long term injecting as well as helping those with a phobia of needles who struggle to stick to the routine required to keep their glucose levels under control.

 

The formulation has already been shown to be neither harmful nor toxic to living tissue, easily manufactured and - unlike some insulin products currently on the market - can be stored at room temperature for up to two months.

 

More research has to be done before clinical trials are approved but we could well be looking at a dramatic transformation in the treatment of insulin-treated diabetes over the next few years.

 

If you would like to read the article that published this research please click here 

 

 

Although every effort is made to ensure that all health advice on this website is accurate and up to date it is for information purposes and should not replace a visit to your doctor or health care professional.

 

As the advice is general in nature rather than specific to individuals Dr Vanderpump cannot accept any liability for actions arising from its use nor can he be held responsible for the content of any pages referenced by an external link

Tags

Acromegaly Addison's disease adolescent diabetes problems adolescent thyroid problems Adrenal crisis adrenal fatigue Adrenal glands Anovulation Autoimmune Thyroiditis Bariatric Surgery blood glucose levels Charcot foot CHT Conception congenital hypothyroidism Consultant Endocrinologist London Cushing's disease Cushing's syndrome Depression Diabetes diabetes and sexual dysfunction diabetes in China diabetes insipidus diabetes latest Diabetic prevalence diabetic retinopathy Disability Act Down's Syndrome Dr Mark Vanderpump endocrine system Freestyle Libre Fruit sugars gestational diabetes Gigantism Glucose Tolerance Test Goitre Graves Disease Graves Orbitopathy guthrie test hair loss Hashimoto's Disease hearing loss Heart Disease heel prick test hyperparathyroidism Hyperthyroidism Hypocalcaemia Hypogonadism hypoparathyroidism hypophysitis Hypothyroidism IFG IGT immunotherapy side effects Impaired Fasting Glucose Impaired Glucose Tolerance Insulin Resistance Iodine IR iron late onset hypogonadism Levothyroxine Low testosterone MEN1 MEN2 mood changes morning sickness Multiple endocrine neoplasia Obesity older patients Osteoporosis overactive thyroid Pancreas Pancreatic Cancer Pancreatic Diabetes parathyroid glands Patient Resources Patient Support Groups PCOS PCOS and Insulin PCOS diet Pituitary Gland POF Polycystic Ovary Syndrome Post menopause thyroid problem Post pregnancy thyroid problem Prader-Willi Syndrome prediabetes pregnancy Pregnancy and Diabetes Pregnancy and Thyroid Disease Premature Ovarian Failure prolactinomas PTH puberty Sheehan's Syndrome Skin tags T4 Tara Palmer Tomkinson testosterone The endocrine system Thyroid Thyroid disease in children thyroid nodules Thyroid Storm Thyroiditis Thyrotoxic Periodic Paralysis Thyroxine TSH levels TSH Testing Type 1 diabetes Type 2 Diabetes Type 3 diabetes underactive thyroid Vitamin D Waist circumference

Please get in touch

Phone: 0203 283 8932

Contact form