Research/Teaching
RESEARCH My MD thesis was an epidemiological twenty-year follow-up study of the Whickham survey which involved determining the outcome in terms of thyroid disorders, diabetes and cardiovascular disease in 2779 subjects. This has provided unique incidence data and risk factors for these disorders. My MD thesis submitted to the University of Birmingham in 1995 was titled "The Incidence of Thyroid Disorders and Diabetes Mellitus in the Community and the Relationship of Thyroid Failure with the Development of Ischaemic Heart Disease". Subsequently my main research interests have been in the field of epidemiology, clinical thyroid disease, audit and the cost-effectiveness of managing thyroid disease. AUDIT I have supervised or participated in the following audits: 1. Development of protocol for the management of thyroid cancer (Vanderpump MPJ, Alexander L, Scarpello JH & Clayton RN. An audit of the management of thyroid cancer in a district general hospital. British Endocrine Societies 1996, Journal of Endocrinology Suppl to Vol 148 P-198). http://www3.interscience.wiley.com/journal/119120411/abstract 2. Audit of strategy of use of TSH alone in thyroid function tests in a DGH laboratory. (Vanderpump MPJ, Manning K, Neary RH & Clayton RN (1996). The third generation thyrotrophin (TSH) assay is not cost-effective in testing for thyroid disease in the community. British Endocrine Societies 1996, Journal of Endocrinology Suppl to Vol 148:OC-19 and Proceedings of 10th International Congress of Endocrinology). http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9488012 3. Analysis of patient knowledge and effectiveness of insulin stress tests performed in patients with pituitary disease within the Department of Endocrinology of the Royal Free Hospital. (Brothwood TA & Vanderpump MP. Safety, accuracy and patients' perspectives of insulin tolerance tests: An audit. Endocrine Society 2001, Endo 2001:P1-627). 4. Audit of use of continuous glucose sensor in insulinomas (Baldeweg SE, Hope S, Tibbals J, Davidson B & Vanderpump M. Use of continuous glucose monitoring system in the medical management of insulinomas. Society for Endocrinology joint with Diabetes UK 2003, Endocrine Abstracts 6:P39/ DP23). http://www.endocrine-abstracts.org/ea/0006/ea0006dp23.htm 5. An audit of patients treated surgically for acromegaly at the National Hospital, Queen Square, demonstrated that transsphenoidal surgery was effective first-line therapy for acromegaly and that less than 50% of patients require adjuvant therapy to provide a cure. (Baldeweg SE, Conway GS, Powell M & Vanderpump M. Single centre audit of surgical outcome in acromegaly. British Endocrine Societies 2003, Endocrine Abstracts 5:P190). http://www.endocrine-abstracts.org/ea/0005/ea0005p190.htm 6. An audit of hypoglycaemia in insulin treated patients with type 2 diabetes. (Hope SJC, Parker C, Vanderpump MPJ. Hypoglycaemia and insulin treated type 2 diabetes - two insulin regimes compared. Diabetes UK 2004, Diabetes Medicine 21 (Suppl 2):P102). 7. An audit of patients with thyrotoxicosis treated at the Royal Free Hospital has provided data on the relapse rate following treatment with anti-thyroid drugs, radioiodine and surgery as well as providing cost-effectiveness data for the three management approaches. (Patel NN, Baker JJ, Abraham P & Vanderpump MPJ. The cost-effectiveness of treatment modalities for thyrotoxicosis - a 2-year follow-up study. American Thyroid Association 2004, Thyroid: 14:700).
http://www.ncbi.nlm.nih.gov/pubmed/16839261?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum 8. Audit and review of the new night-team structure in acute medicine to examine quality of care, training opportunities, leadership and team-building and consultant work-load in conjunction with the Medical Director and Postgraduate Dean.
http://www.ingentaconnect.com/content/rcop/cm/2004/00000004/00000005/art00012 9. A prospective study using continuous subcutaneous insulin infusion (CSII) for type 1 diabetes at the Royal Free Hospital. (Solomon AM, Nethaji C, Holland J, Vanderpump M & Press M. A prospective study using continuous subcutaneous insulin infusion (CSII) for type 1 diabetes in a single centre. Diabetes UK 2008, Diabetes Medicine 25, Suppl 1:OC) 10. Audit of thyroid function testing in a HIV population. (Vanderpump MPJ, Kottegoda R, Madge S, Thomas M, Smith C, Lampe F, Harvey R, Johnson M & Youle M. No association between HIV disease and its treatment and thyroid function. British Thyroid Association Autumn Meeting 2005 and International Thyroid Congress 2005, Thyroid 15 (Suppl. 1):S79-80, and HIV 2006, HIV Medicine 7 (Suppl. 1):P49). http://www3.interscience.wiley.com/journal/118491584/abstract 11. Joint audit with the Department of Clinical Biochemistry to investigate the finding of raised serum FT4 and inappropriately detectable serum TSH. (Han TS, Woolman E, Johri N, Thomas M, & Vanderpump MP. Raised serum FT4 and inappropriately detectable serum TSH: Evaluation of recommendations from UK TFT guidelines. British Endocrine Societies 2008, Endocrine Abstracts 14:P369, and Endo 2008, P1-360). http://www.endocrine-abstracts.org/ea/0015/ea0015p369.htm 12. Joint audit with the Departments of Clinical Biochemistry and Hepatology to determine the incidence of thyroid dysfunction in a Hepatitis C population treated with Interferon and Ribavirin combination therapy (Costelloe S, Wassef N, Morris C, Schulz J, Vaghani T, Thomas M, Jacobs M, Dusheiko G, Vanderpump M. Thyroid dysfunction in a hepatitis C population treated with interferon therapy. British Endocrine Societies 2009, Endocrine Abstracts 19:P353 and American Thyroid Association 2009). http://www3.interscience.wiley.com/journal/123278763/abstract 13. Chair of UK Iodine Study Group on behalf of BTA undertaking assessment of UK iodine status. Vanderpump MPJ on behalf of the UK Iodine Study Group. Assessment of The UK Iodine status: A preliminary report. Joint Annual Meeting of British Thyroid Association and Association of British Endocrine Surgeons, London, November 2009. 14. Development of audit tool for national study of pituitary apoplexy.(Kumar S, Reddy N; Baldeweg S, Han T, Vanderpump M & Wass J. Validity of the new pituitary apoplexy guideline group scoring system (PAGGS) in the management of pituitary apoplexy: a large retrospective review of 46 patients with classical pituitary apoplexy. British Endocrine Societies 2010, Endocrine Abstracts 21:P284). http://www.endocrine-abstracts.org/ea/0021/ea0021p284.htm 15. Audit of introduction of TSH receptor antibody assay. (Theodoraki K, Jones GL, Patel D, Bunn C, Thomas M, Parker J, Bouloux P-M, Vanderpump M. TSH Receptor Antibody assay: its use in a tertiary centre. British Endocrine Societies 2010, Endocrine Abstracts 21:P389).
http://www.endocrine-abstracts.org/ea/0021/ea0021p389.htm
INVITED LECTURES
1. The Whickham survey follow-up - longitudinal studies of the epidemiology of thyroid disease: Thyroid Club, London, 1994. 2. Thyroid disease and diabetes in an English community - the Whickham study revisited: The Endocrine Department, Mayo Clinic, USA, 1995. 3. The twenty-year follow-up of the Whickham survey: Belgium Thyroid Club, Brussels, 1997. 4. Screening for thyroid disease: UK NEQAS, Edinburgh, 1998. 5. Ischaemic heart disease and its relationship to autoimmune thyroid disease: Symposium of 4th European Congress of Endocrinology, Granada, 1998.
6. Subclinical thyroid disease: British Endocrine Societies, Bournemouth, 1999. 7. Epidemiology of nodular goitre: European Thyroid Association, Milan,1999. 8. Population screening for autoimmune thyroid disease: Dutch Thyroid Club, Amsterdam, 1999. 9. Epidemiology of goitre and hypothyroidism: Merck European Thyroid Symposium, Budapest, 2000. 10. Screening for hypothyroidism: British Thyroid Association, London, 2000. 11. How to deal with an elevated TSH: The Glasgow Symposium on Endocrinology, Royal College of Physicians and Surgeons of Glasgow, 2001. 12. Subacute hypothyroidism in the elderly: The Endocrine Society, Denver, 2001. 13. Current knowledge on diagnosing and therapy of thyroid disorders in the UK: prevention of thyroid disease: Satellite Meeting of European Thyroid Association, Aalborg, Denmark, 2001. 14. Management of differentiated thyroid cancer: 11th European Federation of Endocrine Societies Postgraduate Course in Endocrinology, Oxford, 2003. 15. EWTD compliance in Medicine and Surgery: Development of night team at the Royal Free Hospital Trust: National Meeting of NHS Trusts Medical Directors, Royal College of Physicians, London, 2003. 16. What to do with thyroid nodules and goitres: Advanced Medicine Conference, Royal College of Physicians, London, 2004. 17. Subclinical hypothyroidism: Dublin Thyroid Update, Joint Meeting of the BTA and Irish Endocrine Society, Dublin, 2004.
18. Screening for hypothyroidism: Merck European Thyroid Symposium, Berlin, June 2004. 19. Meet the Expert: Subclinical hypothyroidism: The Endocrine Society, New Orleans, June 2004. 20. Practical management of common outpatient problems - "Tired all the Time": Oxford Advanced Endocrinology Seminar, Oxford, 2004. 21. "Weird thyroid function tests": General Internal Medicine for the Physician, Royal College of Physicians, London, 2004. 22. Evidence for diagnosis and management of subclinical thyroid disease: 16th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine, Glasgow, 2005. 23. Thyroid dysfunction in the elderly: The Endocrine Society, San Diego, 2005.
http://www.medscape.com/viewarticle/510284 24. Screening for thyroid disease: The Pathology Section of the Royal Society of Medicine, London, 2005. 25. Subclinical hypothyroidism: 13th International Thyroid Congress, Buenos Aires, 2005. 26. "How I Manage: Thyroiditis": British Thyroid Association Annual Meeting, London, 2006. 27. Clinical Debate "This House believes that all patients with subclinical thyrotoxicosis should be treated: Against the Motion": British Endocrine Societies, Birmingham, 2007.
http://www.endocrine-abstracts.org/ea/0013/ea0013D2.htm 28. UK Guidelines for Thyroid Function Tests: ACB Focus 2007, Manchester, 2007. 29. Imaging in Endocrinology: The thyroid nodule - When and how to assess? Royal College of Radiologists and Society for Endocrinology, London, 2007. 30. Elevated TSH - When do I start thyroxine? Endocrinology for the General Physician, Royal College of Physicians, London, 2007. 31. Diabetes and endocrine disorders in aging people. Management of goitre: Endocrinology and Diabetes Section of RSM and ABCD, London, 2008. 32. Evidence-based medicine. Subclinical hypothyroidism. Endocrinology and Diabetes Section of RSM, London, 2008. 33. Thyroid function and pregnancy. Epidemiology and iodine status. Merck European Thyroid Symposium, Riga, 2008. 34. New drugs and thyroid function. Meet the Expert. European Thyroid Association, Thelassonika, 2008. 35. Subclinical hypothyroidism. British Thyroid Association Annual Meeting, London, 2008. 36. Amiodarone and thyroid disorders. Association of Clinical Biochemists. London, 2009. 37. Adolescent thyroid disease. NorthWest London Paediatric Endocrinologists. London, 2009. 38. Subclinical thyroid disease. Acute and General Internal Medicine for the Physician, Royal College of Physicians, London, 2009. 39. What's new in thyroid disease? Association of British Clinical Diabetologists. London, 2009. 40. Endocrine incidentalomas. Thyroid. British Endocrine Societies, Manchester, March 2010. 41. Subclinical thyroid disease. Acute and General Internal Medicine for the Physician, Royal College of Physicians, Liverpool, 2010. MEDIA INTERVIEWS Diabetes Check-Up BBC Radio 4 June 2006
http://www.bbc.co.uk/radio4/science/checkup_tr_20060406.shtml Independent May 2007
http://www.independent.co.uk/life-style/health-and-wellbeing/health-news/obesity-its-time-to-stop-the-fat-attack-447009.html Thyroid disease Womans Hour BBC Radio 4 May 2003
http://www.bbc.co.uk/radio4/womanshour/2003_19_wed_04.shtml Guardian March 2005
http://www.guardian.co.uk/theguardian/2005/mar/09/features11.g21 Daily Mail September 2006
http://www.dailymail.co.uk/health/article-404724/The-hormone-makes-fat.html Am I Normal? Metabolism BBC Radio 4 November 2006
http://www.bbc.co.uk/radio4/science/am_i_normal_series_2.shtml Times April 2007
http://women.timesonline.co.uk/tol/life_and_style/women/body_and_soul/article1524827.ece Doctor Doctor
Channel 5 August 2007 Case Notes BBC Radio 4 April 2008
http://www.bbc.co.uk/radio4/science/casenotes_tr_20080401.shtml Mens Health Magazine August 2008
http://www.menshealth.co.uk/Health/home-doctor-self-diagnosis-self-help-doctor/217839/v3 Daily Mail January 2010
http://www.dailymail.co.uk/health/article-1240649/Could-indigestion-actually-heart-disease.html Daily Mail March 2010
http://www.dailymail.co.uk/health/article-1254714/Doctors-said-Ali-Jagger-greedy-8-stone-6-months--truth-far-sinister.html Daily Mail March 2010
http://www.dailymail.co.uk/health/article-1160786/Imogen-Lloyd-Webber-I-work-I-kept-piling-weight-Then-I-told-thyroid-gone-haywire.html
Pituitary Disease
Today Programme BBC Radio 4 October 2002
http://news.bbc.co.uk/1/hi/health/2316419.stm
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